Studies of physico-chemical and functional properties of metal binding proteins: parvalbumin, α-lactalbumin, lysozyme, calmodulin, S100 proteins, recoverin and so on. Metalloproteomics.
Studies of roles of metal cations in protein functioning.
Studies of functioning of metal binding proteins in cells.
Studies of natively disordered proteins. Protein-protein interactions.
Development of new methods of molecular design of proteins.
Development of molecular bases of new methods of treatment of oncological diseases.
Search and development of new experimental methods for physico-chemical biology.
Development and studies of registration systems of weak signals of biological objects.
Automation of experiments in physic-chemical biology.
Biological and medical studies. Data treatment: statistical analysis, Fourier- and wavelet-analysis, correlation analysis, signal filtration and approximation.
Development of telemedical system of mobile electrocardiography and systems of telemedical monitoring of pregnancy.
Development of new methods for analysis of Earth surface maps; collection, treatment, systematization, and storage of graphyc, photographic and cartographic materials.
Technological developments
Telemedical system of mobile electrocardiography.
Computer (virtual) рН-meter-ionometer.
Software for DASM-4M microcalorimeter.
Microtitrator with software for the Cary Eclipse (Varian) spectrofluorimeter.
Software for measurements of temperature dependences of luminescence on the Cary Eclipse (Varian) spectrofluorimeter.
New technologies for extraction and purification of biologically active substances from the larch wood.
Stuff
Eugene A. Permyakov, PhD, Doctor of Sci., Prof.
Sergei E. Permyakov, PhD, leading researches, Head of the Protein Res. Group
Vladimir N. Uversky, PhD, Doctor of Sci., leading researcher
Alexander I. Denesyuk, PhD, Doctor of Sci., chief researcher
Alexander A. Kazantsev, PhD, senior researcher, Head of the Group for Biomedical Developments
Anatoly B. Gavrilov, Head of the Group for development of new methods of extraction and purification of biologicaly active substances from wood raw matherials
Valery M. Grischenko, PhD, senior researcher
Victor I. Emelyanenko, PhD, senior researcher
Nadezhda V. Avkhacheva, PhD, senior researcher
Alexei S. Kazakov, PhD, senior researcher
Marina P. Sheveleva, PhD, senior researcher
Julia S. Lapteva, PhD, researcher
Andrei S. Sokolov, researcher
Aliya A. Nazipova, researcher
Maria E. Permyakova, researcher
Ekaterina L. Nemashkalova (Knyazeva), senior researcher
Alisa A. Vologzhannikova, researcher
Elena N. Yundina, postgraduate student
Victoria, A. Rastrygina, postgraduate student
Vara I. Stepanova, Head of the Cartographical group
Ekaterina E. Klam, leading designer
Vladislav I. Sukharev, leading engineer
Evgeny E. Gomov, engineer
Andrei A. Senin, leading engineer
Ludmila V. Kozlovskaya, leading technologist
Sergei M. Deryabin, leading engineer
Olga V. Demchuk, chemical engineer
Svetlana A. Fomenko, lab assistant
Tamara N. Gruznova, lab assistant
Instrumentation and equipment of the lab
IR-Fourier spectrometer, Nicolet-6700, Thermo Scientific, USA
Spectropolarimeter J-810, Jasco, Japan
Spectrofluorimeter Cary Eclipse, Varian, Australia
Spectrophotometer Cary 100, Varian, Australia
High pressure liquid chromatographer LC-10Avp/Prominence, Shimadzu Corp., Japan
Scanning tunnel microscope "Umka", Inst. of Nanotechnologies, Moscow
Multi-color real time PCR system IQ5, BioRad
Gel-scanner Pharos FX Plus, BioRad
Plasmonic resonance system ProteOn XPR, BioRad
Optical microscope (Kyence Biozero)
French press
Dzeta-sizer Nano ZS (Malvern)
Viscosimeter Вискозиметр SV-10 (A&D Company)
Cell sorter
Grants
Grant from SABIT (USA) - 1993
Grant from CAST (USA) - 1993
Grant from Soros - 1994-1995
Grant from NATO - 1994-1996
Grant from Russian Fund for Fundamental Studies - 1998
Grant from NATO - 1999
Grant from Russian Fund for Fundamental Studies - 2001
Grant from INTAS - 2002
Grant from INTAS - 2004
Grant from Russian Fund for Fundamental Studies - 2004
Grant from the RAS Program "Fundamental Sciences for Medicine" - 2004
Grant from the RAS Program "Molecular and Cell Biology" - 2004-2008
Grant from CRDF - 2005
Grant from the Fund for Assistance of Domestic Science - 2006
Grant from the Federal Agency of Science and Innovations - 2006
Grant from the RAS Program "Fundamental Sciences for Medicine" - 2007
Grant from Russian President - 2007-2008
Grant from the RAS Program "Molecular and Cell Biology" - 2009-2010
Grant from the RAS Program "Molecular and Cell Biology" - 2011-2013
Grant from the RAS Program "Fundamental Sciences for Medicine" – 2012
Grant from Russian Fund for Fundamental Studies - 2012
Citation index and Hirsh index of some members of the lab
E.A. Permyakov - 2302, 25
V.N. Uversky - 28391, 87
S.E. Permyakov - 715, 17
Monographs
E.A. Permyakov Parvalbumin and Related Calcium Binding Proteins. Moscow, "Nauka", 1985, 191 p.
E.A. Permyakov Calcium Binding Proteins. Moscow, "Nauka", 1993, 190 p.
E.A. Permyakov, Luminescent Spectroscopy of Proteins. CRC Press, Boca Raton, Ann Arbor, London, Tokyo, 1993, 164 p.
E.A. Permyakov, Intrinsic Protein Fluorescence Method. Moscow, "Nauaka", 2003, 189 p.
I.N. Stepanov The Theory of Relief Plastics and New Subject Maps. Moscow, "Nauka", 2006, 229 p.
Permyakov, E.A. ?-Lactalbumin. Nova Science Publishers, New York, 2005, 136 p.
Permyakov, E.A. Parvalbumin. Nova Science Publishers, New York, 2006, 196 p.
Permyakov, E.A. Metalloproteomics. A John Wiley & Sons, Inc., Hoboken, New Jersey, 2009, 786 p.
Permyakov, E.A., and Kretsinger, R.H. Calcium Binding Proteins. A John Wiley & Sons, Inc., Hoboken, New Jersey, 2011, 573 p.
Morozova, L.A., Berliner, L.J., and Permyakov, E.A. Calcium Binding Lysozymes. Nova Science Publishers, New York, 2012.
Permyakov, E.A. Metal Binding Proteins: Structure, Properties, Functions. Scientific World, Moscow, 2012, 544 p.
Collected articles
Methods in Protein Structure and Stability Analysis. Part A. Luminescence Spectroscopy and Circular Dichroism. Nova Biomedical Books, New York, 2007, V.N. Uversky & E.A. Permyakov, eds.
Methods in Protein Structure and Stability Analysis. Part B. Vibrational Spectroscopy. Nova Biomedical Books, New York, 2007, V.N. Uversky & E.A. Permyakov, eds.
Methods in Protein Structure and Stability Analysis. Part С. Conformational Stability, Size, Shape and Surface of Protein Molecules. Nova Biomedical Books, New York, 2007, V.N. Uversky & E.A. Permyakov, eds.
Methods in Protein Structure and Stability Analysis. Part С. NMR and EPR Spectroscopies, Mass-Spectrometry and Protein Imaging. Nova Biomedical Books, New York, 2008, V.N. Uversky & E.A. Permyakov, eds.
Kaleidoscope of Structural Properties and Functions, Research Singpost, Kerala, India, 2003, Ed. V.N. Uversky.
The Wiley Series in Protein and Peptide Science (Uversky V.N. series Ed.), John Wiley & Sons, Inc, Hoboken, New Jersey, USA. ISBN: 978-0-470-59169-7 (2012)
Methods and Experimental Tools (Editors: Uversky V.N., Dunker A.K.), Humana Press, Totowa, NJ, USA. ISBN: 978-161-77-9926-6 (2012)
PhD and Doctor dissertations
Deikus, U.J., 1996, PhD
Veprintsev, D.B., 1998, PhD
Uversky, V.N., 1998, Doctor of Sci.
Permyakov, S.E., 2001, PhD
Morozova-Rosh, L.A., 2002, Doctor of Sci.
Zhadan, A.P., 2003, PhD
Bakunts, A.G., 2009, PhD
Kazantsev, A.P., 2009, PhD
Knyazeva, E.L., 2010, PhD
Senin, A.A., 2012, PhD
Lapteva, Y.S., 2012, PhD
Collaboration
The lab collaborates with the following scientific organizations
Denver University, Denver, CO, USA
University of South Florida, Tampa, FL, USA
Abo Akademi University, Turku, Finland
Umea University, Umea, Sweden
Moscow State University, Moscow, Russia
Branch of the Institute of Bioorganic chemistry of the RAS, Puschino, Moscow region
Institute of theoretical and experimental Biophysics of the RAS, Puschino, Moscow region
Protein Research Group of the Laboratory of New Methods for Biology of the IBI RAS invites graduate students (master’s degree) to join postgraduate course in molecular biophysics.
